Effect of lidocaine, atracurium and diazepam pretreatments on post-suxamethonium muscle fasciculations and intubating conditions

This study was designed to evaluate the effect of lidocaine, atracurium and diazepam pretreatments on the incidence and severity of post-suxamethonium muscle fasciculations and on the intubating conditions. 200 patients of both sexes undergoing different surgical procedures were subjected to this study. These patients were divided into four equal groups. All patients were premedicated 30 minutes before induction of anaesthesia by 0.01 mg/kg IM. Two minutes before induction 5 cc saline [as placebo], 3 mg/kg lidocaine, 2.5 mg atracurium and 5 mg diazepam were injected intravenously in the 1st [control], 2nd, 3rd and 4th group respectively. Anaesthesia was induced by thiopentone Na [5 mg/kg] intravenously followed by IV administration of 1 mg/kg suxamethonium to facilitate endotracheal intubations and it was maintained under halothane and oxygen. After suxamethonium administration, the incidence and the severity of muscle fasciculations beside the intubating conditions were evaluated and recorded in a double blind fashion among the patients of this study. From this study it was found that all pretrearments reduced both the incidence and severity of muscle fasciculations. The most effective one was atracurium followed by lidocaine and then by diazepam pretreatment. Numerically but not statistically. intubating conditions were the best in lidocaine pretreated group followed by control group then by diazepam pretreated group and lastly by atracurium pretreated one

Analgesic effect of intrathecal doxapram

This work was designed to define whether intrathecal doxapram has or not an analgesic effect. 20 clinically free adult dogs of both sexes were subjected to this study, these dogs were divided into 2 equal groups [I and II]. These dogs were prepared for lumber spinal injection and complete aseptic precautions were done during intrathecal administration of the drug. The site of injection was the space between the 4th and 5th lumbar vertebrae. After injection of either doxapram [0.25 mg/kg] or distilled water [2 cc as placebo] in group I and group II respectively, dogs were left to stand. Continuous observations and testing for signs of autonomic, sensory and motor nerve block were done. Dogs of both groups were examined daily for 7 days after the day of injection to find out any post-injection side effects. On the 7th day, all dogs were sacrificed by electric shock and specimens from the lumbar parts of their spinal cords and meninges were taken far histopathological examination. This study proved that intrathecal doxapram has a short-lived local analgesic effect in dogs without post-injection side effects

Intravenous doxapram for prevention and control of post-extubation laryngospasm

This work was designed to study the effect of I.V. administration of doxapram to prevent the occurence of post-extubation spasm in children.Two hundred children undergoing tonsillectomy were the subject of this double-blind study. One minute before extubation either 15mg/Kg doxapram [diluted up to 10cc. with saline] or 10cc. saline [as a placebo] was I.V. adminsitered. It was found that doxapram produced a very highly significant reduction in both the incidence and severity of post-extubation laryngospasm with transient significant increase in heart rate, transient highly significant increase in tidal volume and a very highly significant decrease in recovery period

value of IV fluid administration during and after minor surgical procedure

This work was designed to study the value of I. V. administration of 1 litre of Ringer lactate solution during and another litre of 5% dextrose solution after minor surgical procedures. Two hundred patients of both sexes undergoing minor operative procedures were the subject of this study.These patients were divided into two equal groups. All patients were premedicated 30 minutes before induction of anaesthesia by 0.01 mg/Kg atropine sulphate I.M. Anaesthesia was induced by thiopentone Na and maintained under fluothane and oxygen. The first group was not given any I.V. fluids during and 6 hours after operation and served as conrrol group. The, second group was given 1 litre of Ringer lactate solution during operation and another litre of 5% dextrose solution postoperatively and served as treated group. From this study it was found that, fluid administration during and after minor surgical procedures enhanced the recovery from anaesthesia, decreased the commonly occuring bad post-operative subjective feelings, amelurated extracellular fluid volume and tonicity changes and prevented fat utilization

comparative study on the effect of fentanyl and d-tubocurarine pretreatments of intra-ocular pressure

This work was designed to compare the effect of fentanyl and d-tubocurarine pretreatments on normal intraocular pressure [lOP] during general anaesthesia. One hundred patients of both sexes and middle age submitted to elective ophthalmic surgery were the subject of this comparative study.These patients were divided into two equal groups. All patients were premedicated by 0.01 mg/kg atropine sulphate I.M. Two minutes before induction 2 ug/kg fentanyl and 0.05 mg/kg d-tubocurarine were I.V. injected in the first and the second group respectively. Anaesthesia was induced by thiopentone Na followed by suxamethonium [1 mg/kg] and endotracheal intubation and was maintained under fluothane and oxygen. From this study, it was found that fentanyl pretreatment was superior to d-tubocurarine as pretreatment of control lOP especially during suxamethonium administration and endotracheal intuabation